Oh me, oh life

I always think that my writing voice is more pretentious than I am in real life and that prevents me from writing on the internet.

Or maybe that’s just me internalizing that, since I’ve seen other blogs dripping with conceit (this obviously does not apply to those reading this – all two of you, hah, are beautiful writers :) ).

Que cera cera.

I love graduate school. The people from every walk of life and every profession is so …invigorating! I had my doubts when apply to a ~private~ school but I am really happy to be going here. It seems like every week I make a new connection with someone fascinating. A year ago I would think that I was being too cheesy but now I believe it.

And the professors!
Let me make a disclaimer: I miss Georgia Tech, in all its nerdy glory. I really appreciate the holistic scientific and mathematical background I got from there.
However, even my most beloved professors were first married to their research. But here, people want to teach! People take time and hop on over from the CDC to teach you programming or whatever it may be. And the female teaching proportion is empowering, haha.
(I also made that comment about Contagion; that their representation of epidemiologists (2/3 women, off the top of my head) was really quite accurate)

P.S. – I finally understand what the ANOVA statistic is for, hah! I love math :)

Job

Well, I just came back from my interview – I got a job!

It’s writing promotional pieces for the school’s technologies.

 

So, I should probably practice here, yeah?

:crickets:

Gettin’ SASsy

So, as it’s turning out, some of my favorite classes so far are Biostatistics and Programming. Hm.

Am I going to turn into the dreaded cubicle-bound, melanin-inept programmer my sister always warned me about? Or will it just let me get an awesome job? You decide.

 

 

(also, yes I’m updating this! woohoo)

Graduate schooling

Just got my EMORY email up and running! :)

Taking only two classes makes me feel like I’m in limbo — but I get to register for my first graduate courses in a few weeks! So excited!

On the road again…

School tomorrow, for the first time, haha. Snow snow snow. I think wishing for it my whole life made it downpour.

 

I’m happy for the longer break we had, I think I needed it mentally. Now I’m ready to begin the Best Semester Ever. (and maybe last?!)

New Semester…. maybe

So, there is snow scheduled at the same time as my classes, guess which one I’m going to..

But since I do want to get in the habit of blogging, I will write about my classes that I will be taking in 24 hours (ish):

Physics II (ohh, scary!)
Intro to Evolution (cogito ergo sum?)
Ancient Rome (quo vadis?)
Regulatory RNA’s
Senior Seminar
Senior Research (at the zoo!)

There’s more Latin in there than I expected, haha.

 

 

 

Windows 7 Paint is pretty neat

Resolution

2011, hello!

So, for this year I want to keep a good ol’ active blog. So, I want to participate in the Post-A-Week 2011 challenge, with this being the first one for the new year!

Happy New Year!

Happy 2011!

I hope everyone has been having a wonderful holiday!
Come on 2011, give me your best shot!

Walks Like a Duck, Stings like a Platypus



Defensins and the convergent evolution of platypusand reptile venom genes

http://genome.cshlp.org/content/18/6/986.short

Platypuses are one of the few mammals, and the only monotreme to be venomous. The males have a spur on the hind legs that is able to inject quite potent neurotoxic venom from an internal venom gland into its victim. While this is only used during the mating season for the platypus, many other organisms use this same mode of envenomation. In this paper, several scientists analyzed the platypus genome for “venomics”, or the genes that contribute to an organism being venomous. In this genome,  Ornithorhynchusvenom defensin-like peptide (OvDLP) genes were identified to create the majority of the proteins for venom.

Through the analysis of where alpha- and beta-defensin genes arelocated on the platypus’ chromosomes, and how other similar genes were placed on other organism’s chromosomes, a phylogenic tree was constructed (as seen above). It was also used to genetically date the platypus as emerging before the splitting of the other two mammalian domains.

However, they conclude that while platypuses did not evolve from poisonous reptillians, they did experience convergent evolution. They believe that they both contain genes from a ancestral synteny group A.

Long in the Tooth or Old in the Blood?

http://www.jyi.org/articleimages/821/originals/img0.jpg

 

Estimating human age from T-cell DNA arrangements

http://www.cell.com/current-biology/abstract/S0960-9822(10)01286-8

 

Gathering evidence from blood samples is particularly important for forensics and the judiciary system. If you are not able to accurately and definitively make conclusions on blood evidence, then it becomes harder to incriminate the perpetrator. In the following paper, they propose that analyzing T-cell DNA from a blood sample can accurately pinpoint the age of the subject the blood belonged to.

Their proposition relies on the fact that T-cells, while still in the thymus, will undergo somatic rearrangement to optimize the number and diversity of receptors for antibodies that are present on the T-cells, or T-cell receptors (TCR). It’s during this time that pieces of the DNA will be excised and ”circularized into episomal DNA molecules”. These are called single joint TCR excision circles (sjTRECs). The quantity of these is directly correlated to a person’s age, as seen in the below figure:

 

However, they admit that they need to do further studies, to account for gender differences and those with immunological diseases (including, but not limited to, HIV and autoimmune diseases). However, this is still a breakthrough and relevant to many fields.

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